Rezistenca ndaj insulin\u00ebs \u00ebsht\u00eb nj\u00eb gjendje n\u00eb t\u00eb cil\u00ebn p\u00ebrqendrimet normale t\u00eb insulin\u00ebs prodhojn\u00eb m\u00eb pak se normalja e p\u00ebrgjigjes biologjike. Ose mund t\u00eb quhet edhe nj\u00eb gjendje e rezistenc\u00ebs ndaj efekteve metabolike t\u00eb insulin\u00ebs. Efektet metabolike t\u00eb insulin\u00ebs jan\u00eb shtypja e glukoz\u00ebs s\u00eb prodhuar n\u00eb m\u00ebnyr\u00eb endogjene, stimulimi i mbajtjes periferike t\u00eb glukoz\u00ebs (kryesisht n\u00eb muskuj) dhe glukoneogjeneza, dhe shtypja e lipoliz\u00ebs n\u00eb indin dhjamor.<\/p>\n\n\n\n
Normalisht, insulina shtyp prodhimin e glukoz\u00ebs (sheqerit) n\u00eb m\u00ebl\u00e7i duke frenuar glukoneogjenez\u00ebn (shnd\u00ebrrimin e substancave t\u00eb tjera n\u00eb sheqer) dhe glikogjenoliz\u00ebn (shnd\u00ebrrimin e glikogjenit, i cili \u00ebsht\u00eb nj\u00eb sheqer depozitues, n\u00eb sheqer). Ai gjithashtu transporton glukoz\u00ebn n\u00eb indet periferike si muskujt dhe indet yndyrore, ku ose ruhet si glikogjen ose oksidohet p\u00ebr t\u00eb prodhuar energji. Pra, rezultati neto \u00ebsht\u00eb se sheqeri n\u00eb gjak bie. N\u00eb rezistenc\u00ebn ndaj insulin\u00ebs<\/p>\n\n\n\n
Rezistenca ndaj k\u00ebtyre efekteve t\u00eb insulin\u00ebs n\u00eb m\u00ebl\u00e7i, muskuj dhe indet dhjamore shfaqet dhe efekti i uljes s\u00eb glukoz\u00ebs n\u00eb m\u00ebl\u00e7i \u00ebsht\u00eb i d\u00ebmtuar. Mbajtja e glukoz\u00ebs me nd\u00ebrmjet\u00ebsimin e insulin\u00ebs n\u00eb muskuj dhe indet dhjamore gjithashtu zvog\u00eblohet. N\u00eb k\u00ebt\u00eb rast, insulina n\u00eb mjedis p\u00ebrpiqet t\u00eb ul\u00eb sheqerin n\u00eb gjak duke rritur mjaftuesh\u00ebm insulin\u00ebn p\u00ebr t\u00eb p\u00ebrmbushur k\u00ebt\u00eb rezistenc\u00eb. K\u00ebshtu, p\u00ebr t\u00eb ulur sheqerin n\u00eb gjak, qelizat beta punkreatike rrisin vazhdimisht sekretimin e insulin\u00ebs. Si rezultat, nd\u00ebrsa niveli normal i sheqerit ruhet, niveli i insulin\u00ebs \u00ebsht\u00eb 2 her\u00eb m\u00eb i lart\u00eb se normalja. Kjo b\u00ebn q\u00eb pankreasi t\u00eb punoj\u00eb me kapacitet t\u00eb tepruar.<\/p>\n\n\n\n
Megjith\u00ebse rezistenca ndaj insulin\u00ebs \u00ebsht\u00eb e zakonshme n\u00eb diabetin e tipit 2 dhe obezitetin, ajo \u00ebsht\u00eb zbuluar n\u00eb 25% t\u00eb individ\u00ebve t\u00eb sh\u00ebndetsh\u00ebm q\u00eb nuk jan\u00eb obez\u00eb dhe kan\u00eb nj\u00eb OGTT normal dhe n\u00eb 25% t\u00eb pacient\u00ebve me hipertension esencial (rezistenc\u00eb ndaj insulin\u00ebs). Prandaj, rezistenca ndaj insulin\u00ebs \u00ebsht\u00eb nj\u00eb gjendje e zakonshme dhe e zakonshme n\u00eb shoq\u00ebri. N\u00eb vitin 1988, Reaven vuri re se mbipesha, diabeti, hipertensioni, hiperlipidemia dhe s\u00ebmundjet aterosklerotike t\u00eb zemr\u00ebs u gjet\u00ebn tek i nj\u00ebjti pacient m\u00eb shpesh sesa rast\u00ebsi, dhe sugjeroi se ato ishin shkaktuar nga i nj\u00ebjti \u00e7rregullim metabolik. Bazuar n\u00eb k\u00ebt\u00eb, Reaven p\u00ebrshkroi sindrom\u00ebn e rezistenc\u00ebs ndaj insulin\u00ebs (sindroma Ky grup s\u00ebmundjesh u quajt m\u00eb von\u00eb sindroma metabolike, nd\u00ebr t\u00eb cilat diabeti jo i varur nga insulina, hipertensioni esencial dhe s\u00ebmundjet koronare t\u00eb zemr\u00ebs jan\u00eb gjithnj\u00eb e m\u00eb shum\u00eb p\u00ebrgjegj\u00ebs p\u00ebr s\u00ebmundshm\u00ebrin\u00eb dhe vdekshm\u00ebrin\u00eb, por lidhja midis tyre dhe rezistenc\u00ebs ndaj insulin\u00ebs \u00ebsht\u00eb sqaruar vet\u00ebm pjes\u00ebrisht.<\/p>\n\n\n\n
Duhet t\u00eb ket\u00eb disa kritere q\u00eb t\u00eb mund t\u00eb thuash rezistenc\u00eb ndaj insulin\u00ebs. K\u00ebto:<\/p>\n\n\n\n
Hiperinsulinemia (1\/4 e sip\u00ebrme e popullsis\u00eb jo diabetike)<\/p>\n\n\n\n
Pozitiviteti i dy ose m\u00eb shum\u00eb nga sa vijon:<\/p>\n\n\n\n
Glukoza plazmatike e agj\u00ebrimit > 110 mg\/dl<\/p>\n\n\n\n
Presioni i gjakut > 140\/90 mmHg<\/p>\n\n\n\n
TG (Trigliceride) > 200 mg\/dl<\/p>\n\n\n\n
HDL < 50 mg\/dl<\/p>\n\n\n\n
Perimetri i belit > 94 cm (mashkull)<\/p>\n\n\n\n
Perimetri i belit > 80 cm (fem\u00ebr)<\/p>\n","protected":false},"excerpt":{"rendered":"
Rezistenca ndaj insulin\u00ebs \u00ebsht\u00eb nj\u00eb gjendje n\u00eb t\u00eb cil\u00ebn p\u00ebrqendrimet normale t\u00eb insulin\u00ebs prodhojn\u00eb m\u00eb pak se normalja e p\u00ebrgjigjes biologjike. Ose mund t\u00eb quhet edhe nj\u00eb gjendje e rezistenc\u00ebs ndaj efekteve metabolike t\u00eb insulin\u00ebs. Efektet metabolike t\u00eb insulin\u00ebs jan\u00eb shtypja e glukoz\u00ebs s\u00eb prodhuar n\u00eb m\u00ebnyr\u00eb endogjene, stimulimi i mbajtjes periferike t\u00eb glukoz\u00ebs (kryesisht […]<\/p>\n","protected":false},"author":1,"featured_media":28148,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[117],"tags":[],"class_list":["post-29159","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-sq"],"_links":{"self":[{"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/posts\/29159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/comments?post=29159"}],"version-history":[{"count":0,"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/posts\/29159\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/media\/28148"}],"wp:attachment":[{"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/media?parent=29159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/categories?post=29159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drburakkavlakoglu.com\/sq\/wp-json\/wp\/v2\/tags?post=29159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}